With over 20 years of experience in serving pharmaceutical industry, Druglike Consulting provides ADME/DMPK help across the Europe, with expertise that helps you to navigate the complex landscape of drug absorption, distribution, metabolism and excretion with confidence.
Decades of hands-on experience in a CRO environment, and a track record with numerous of compound families and multiple drug modalities. Understanding of the experimental details of preclinical ADME/DMPK studies, with expert interpretation of the data to accelerate your projects.
No two projects are alike, and neither are the solutions. Let’s take a look to your projects specific properties and challenges, and design strategy and studies to address the needs to ensure you will get exactly the data and insights required.
Emphasis on collaboration and accessibility, approach that focuses on clear communication and building relationships, translating complex ADME data into actionable insights that your team can understand.
Strategies to optimize ADME/DMPK and DDI properties through your project, from discovery to lead optimisation, candidate selection and later preclinical development, across multiple drug modalities.
Designing ADME screening & selection cascades on assay level, as well as individual ADME/DMPK/DDI studies through preclinical development, answering your specific questions regarding your compounds.
Preclinical ADME gap analysis for development programs at IND stage, and planning DMPK/DDI studies to fulfill the needs for regulatory agencies.
Guidance in interpretation of in vitro & in vivo ADME/DMPK results, in vitro – in vivo extrapolation (IVIVE) of the data, and evaluation of in vitro – in vivo correlation (IVIVC) to pinpoint disconnections and plan further studies. Let’s translate complex datasets to clear insights and concrete recommendations!
Do you have tricky compounds, low quality data, mismatch in in vitro – in vivo correlation or mismatches between results from different assays? Let’s review the assay details & their results, and find a path towards better understanding the behaviour or your compounds.
Help in setting up LC/MS methods for various type of compounds, taking account chromatographic behaviour and mass spectrometric ionisation. For high-throughput screening, quantitative bioanalysis and for drug metabolite identification.
Help in selecting a suitable contract laboratory for your studies, including pre-study-discussions, contracts, collaboration and study monitoring.
The effective ADME strategy requires recognizing characteristics of each compound family and project. Physicochemistry, molecular size, acid/base-nature, to name a few, as well understanding regarding unbound fractions in vitro & in vivo. As the routine protocols often fail to produce useful data, the required assays and their study desing may require tailoring, to capture the properties and tame the challenges of your compounds. Let’s take a look to your project and develop specialised approaches for the needs of your projects!
Send a message to discuss how flexible ADME/DMPK consulting can support your develoment goals.
